Bicarbonate/lactate- and bicarbonate-buffered peritoneal dialysis fluids improve ex vivo peritoneal macrophage TNFalpha secretion.
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چکیده
منابع مشابه
Bicarbonate/lactate- and bicarbonate-buffered peritoneal dialysis fluids improve ex vivo peritoneal macrophage TNFalpha secretion.
Peritoneal macrophage (PMO) function was examined ex vivo after their in vivo exposure to either acidic, lactate-buffered solutions (PD4; 40 mM lactate, pH 5.2), bicarbonate/lactate-buffered solution (TBL; 25 mM/15 mM bicarbonate/lactate, pH 7.3), or bicarbonate-buffered solution (TB; 38 mM bicarbonate, pH 7.3), containing either 1.36 or 3.86% glucose. Initial experiments demonstrated that tumo...
متن کاملImproved in vitro biocompatibility of bicarbonate-buffered peritoneal dialysis fluid.
BACKGROUND Conventional peritoneal dialysis fluids (PDFs) have been shown to damage the mesothelial layer and are associated with the development of peritoneal fibrosis and neoangiogenesis. New-generation PDFs have therefore been developed with physiological pH and reduced levels of glucose degradation products (GDPs), precursors of advanced glycation end products (AGEs). In this work, we evalu...
متن کاملGeneration of TNFalpha and interleukin-6 by peritoneal macrophages after overnight dwells with bicarbonate- or lactate-buffered dialysis fluid.
OBJECTIVE In order to evaluate the biocompatibility profile of a newly designed peritoneal dialysis fluid (PDF), we evaluated peritoneal leukocyte (PMphi) cytokine release following overnight in vivo dwells using standard, lactate-buffered, single-chamber bag PDF (Lac-PDF) and purely bicarbonate-buffered, double-chamber bag PDF containing 34 (Bic-PDF) or 39 (Bic Hi-PDF) mmol/L bicarbonate. DE...
متن کاملCytotoxic Glucose Degradation Products in Fluids for Peritoneal Dialysis
During the standard heat sterilization process of the lactate–buffered peritoneal dialysis solutions, glucose (an osmotic active substance) degrades to form compounds called glucose degradation products which are cytotoxic and affect the survival of the peritoneal membrane. This case presentation is based on an observation of 224 aseptic peritonitis cases of unknown etiology. For the purpose of...
متن کاملPeritoneal Dialysis
La,dialyse peritoneale constitue une methode d,epuration extra-renale simple,efficqCe et d,un prix de revient modere. La dialyse peritoneale,ne necestite aueuneinstalation complexe,peut-etre consideree comme une methode de reanimation non specialisedont la vulgarosation doit permettre: De traiter surplace d,une maniere intensive et prophylactique les nombreuses insuffisances renales aiPue...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1998
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v981499